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Molecularly, EMT is characterized by downregulation of epithelial junction proteins (e.g., E-Cadherin and Occludins) and activation of EMT transcriptional activators (e.g., Snail, Slug, and Twist) and mesenchymal markers (e.g., S100A4, Vimentin, Fibronectin, and N-Cadherin) [63]

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Hartwig, Stver, & Weilandt, 2008) [14] (N

The decline in the numbers caused the tobacco industry to consolidate and they closed many of their manufacturing plants, although tobacco still generates $121 billion annually in the United States

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